Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer
نویسندگان
چکیده
Esophageal cancer is a disease showing poor prognosis. Although combination chemotherapy using cisplatin (CDDP) and 5-fluorouracil standard for unresectable esophageal cancer, the response rate 35%. Cancer stem cells (CSCs) inflammation are reportedly responsible prognosis of cancer. However, comprehensive analyses have not been conducted proposals progress remain lacking. Iron known to be key factor in stemness CSCs. Our study focused on therapeutic potential iron control chelators CSCs Among 134 immunohistochemically analyzed cases, Nanog expression was high 98 cases low 36 cases. High correlated with overall disease-free survivals. The deferasirox (DFX) SP10 suppressed proliferation markers TE8 OE33 cells. DFX did induce compensatory interleukin (IL)-6 secretion, although CDDP result induction. Moreover, BBI608 SSZ, as other CSC-targeting drugs, could suppress markers. Overall, appears related patients, inhibition IL-6 secretion by may offer novel strategy
منابع مشابه
Apelin: A promising therapeutic target? (Part 1)
Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...
متن کاملA Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis
There is a high prevalence of infections caused by Leishmania parasites and increasing rate of drug resistance. Lack of successful treatment with existing drugs calls for new therapeutic approaches. The main strategy in treatment of leishmaniasis is creating apoptosis and eliminating different forms of the parasite. So far, numerous drugs with specific mechanisms including 14-α-demethylase enzy...
متن کاملHepcidin: A Promising Therapeutic Target for Iron Disorders
Iron is required for most forms of organisms, and it is the most essential element for the functions of many iron-containing proteins involved in oxygen transport, cellular respiration, DNA replication, and so on. Disorders of iron metabolism are associated with diverse diseases, including anemias (e.g., iron-deficiency anemia and anemia of chronic diseases) and iron overload diseases, such as ...
متن کاملCDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer
Triple negative breast cancers exhibit very aggressive features and poor patient outcomes. These tumors are enriched in cancer stem cells and exhibit resistance to most treatments and chemotherapy. In this study, we found the cyclin-dependent kinase (CDK4) to act as a cancer stem cell regulator and novel prognostic marker in triple negative breast cancers. We found CDK4 to be highly expressed i...
متن کاملSkp2 is a Promising Therapeutic Target in Breast Cancer
Breast cancer is the most common type of cancer among American women, and remains the second leading cause of cancer-related death for female in the United States. It has been known that several signaling pathways and various factors play critical roles in the development and progression of breast cancer, such as estrogen receptor, Notch, PTEN, human epidermal growth factor receptor 2, PI3K/Akt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2021
ISSN: ['1097-0215', '0020-7136']
DOI: https://doi.org/10.1002/ijc.33544